SAMe is the amino acid methionine, known to bind to ATP molecules that circulate in the blood acting as a 'methyl' donor and known to boost the levels of the neurotransmitters serotonin, dopamine and norepinephrine. SAMe is specifically designed to address the deficiency of these transmitters and contribute to its antidepressant action. Organika's SAMe is manufactured for maximum absorption using clear coated tablets, and 400mg per tablet to provide the highest potency.